| Date | Name | Shares | Transaction | Value |
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
N/A
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 |
0.00
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
7,141
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $940.46 per share |
6,715,824.86
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
6,159
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $941.58 per share |
5,799,191.22
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
7,250
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $644.54 per share |
4,672,915.00
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
7,716
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $939.57 per share |
7,249,722.12
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
4,272
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $945.61 per share |
4,039,645.92
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
2,478
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 |
0.00
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
N/A
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $950.76 per share |
0.00
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
4,415
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $943.53 per share |
4,165,684.95
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
4,307
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $944.22 per share |
4,066,755.54
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
5,772
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $726.53 per share |
4,193,531.16
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
500
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 |
0.00
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
8,155
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $492 per share |
4,012,260.00
|
|
Nov 9, 2026
| Jason Pitofsky SVP Controller |
4,944
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $942.31 per share |
4,658,780.64
|
|
Nov 6, 2026
| Huda Y. Zoghbi Director |
N/A
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 |
0.00
|
|
Nov 6, 2026
| Huda Y. Zoghbi Director |
9,142
| Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $380.95 per share |
3,482,644.90
|
|
Nov 6, 2026
| Huda Y. Zoghbi Director |
2,203
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $970.42 per share |
2,137,835.26
|
|
Nov 6, 2026
| Huda Y. Zoghbi Director |
1,703
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $971.06 per share |
1,653,715.18
|
|
Nov 6, 2026
| Andrew J. Murphy Co-Chief Scientific Officer |
46,779
| Bona fide gift |
0.00
|
|
Nov 5, 2026
| Christine A. Poon Director |
5,219
| Open market or private sale of non-derivative or derivative security Non-derivative transaction at $971.31 per share |
5,069,266.89
|