septerna inc - SEPN

SEPN

Close Chg Chg %
22.00 0.11 0.50%

Open Market

22.11

+0.11 (0.50%)

Volume: 309.62K

Last Updated:

Oct 23, 2025, 1:43 PM EDT

Company Overview: septerna inc - SEPN

SEPN Key Data

Open

$22.09

Day Range

21.10 - 22.45

52 Week Range

N/A - N/A

Market Cap

$980.87M

Shares Outstanding

44.59M

Public Float

26.76M

Beta

4.19

Rev. Per Employee

N/A

P/E Ratio

N/A

EPS

-$2.15

Yield

0.00%

Dividend

N/A

EX-DIVIDEND DATE

SHORT INTEREST

N/A

AVERAGE VOLUME

352.23K

 

SEPN Performance

1 Week
 
-0.27%
 
1 Month
 
26.07%
 
3 Months
 
58.50%
 
1 Year
 
N/A
 
5 Years
 
N/A
 

SEPN Analyst Ratings

  • Sell
  • Under
  • Hold
  • Over
  • Buy
Number of Ratings 4
Full Ratings ➔

About septerna inc - SEPN

Septerna, Inc. is a clinical-stage biotechnology company, which engages in pioneering a new era of G protein-coupled receptor oral small molecule drug discovery powered by proprietary Native Complex PlatformTM. Its pipeline of product candidates focused initially on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. The company was founded by Robert Joseph Lefkowitz, Arthur Christopoulos, Patrick Sexton, and Jeffrey T. Finer in December 2019 and is headquartered in South San Francisco, CA.

SEPN At a Glance

Septerna, Inc.
250 East Grand Avenue
South San Francisco, California 94080
Phone 1-650-338-3533 Revenue 1.08M
Industry Pharmaceuticals: Major Net Income -71,798,000.00
Sector Health Technology 2024 Sales Growth 611.921%
Fiscal Year-end 12 / 2025 Employees 75
View SEC Filings

SEPN Valuation

P/E Current N/A
P/E Ratio (with extraordinary items) N/A
P/E Ratio (without extraordinary items) N/A
Price to Sales Ratio 946.303
Price to Book Ratio 2.422
Price to Cash Flow Ratio N/A
Enterprise Value to EBITDA -8.711
Enterprise Value to Sales 643.561
Total Debt to Enterprise Value 0.037

SEPN Efficiency

Revenue/Employee 14,333.333
Income Per Employee -957,306.667
Receivables Turnover 0.956
Total Asset Turnover 0.004

SEPN Liquidity

Current Ratio 27.771
Quick Ratio 27.771
Cash Ratio 27.311

SEPN Profitability

Gross Margin -30.326
Operating Margin -7,518.419
Pretax Margin -6,725.209
Net Margin -6,678.884
Return on Assets -24.445
Return on Equity -27.048
Return on Total Capital -16.115
Return on Invested Capital -25.322

SEPN Capital Structure

Total Debt to Total Equity 6.065
Total Debt to Total Capital 5.718
Total Debt to Total Assets 5.58
Long-Term Debt to Equity 5.624
Long-Term Debt to Total Capital 5.303
  • Income Statement
  • Balance Sheet
  • Cash Flow Statement

Annual Financials for Septerna Inc - SEPN

Collapse All in section
All values USD millions. 2022 2023 2024 5-year trend
Sales/Revenue
- - 151.00K 1.07M
-
Sales Growth
- - - +611.92%
-
Cost of Goods Sold (COGS) incl D&A
- 577.00K 848.00K 1.40M
COGS excluding D&A
- - - -
-
Depreciation & Amortization Expense
- 577.00K 848.00K 1.40M
Depreciation
- - - 1.40M
-
Amortization of Intangibles
- - - -
-
COGS Growth
- - +46.97% +65.21%
-
Gross Income
- (577.00K) (697.00K) (326.00K)
Gross Income Growth
- - -20.80% +53.23%
-
Gross Profit Margin
- - -461.59% -30.33%
-
2022 2023 2024 5-year trend
SG&A Expense
- 27.39M 44.85M 80.50M
Research & Development
- 22.04M 35.98M 65.34M
Other SG&A
- 5.35M 8.87M 15.16M
SGA Growth
- - +63.76% +79.47%
-
Other Operating Expense
- - - -
-
Unusual Expense
- - - -
-
EBIT after Unusual Expense
- (27.97M) (45.55M) (80.82M)
Non Operating Income/Expense
- 291.00K 50.42M 8.53M
Non-Operating Interest Income
- 291.00K 2.79M 8.62M
Equity in Earnings of Affiliates
- - - -
-
Interest Expense
- - - -
-
Interest Expense Growth
- - - -
-
Gross Interest Expense
- - - -
-
Interest Capitalized
- - - -
-
Pretax Income
- (27.68M) 4.87M (72.30M)
Pretax Income Growth
- - +117.60% -1,584.21%
-
Pretax Margin
- - +3,225.83% -6,725.21%
-
Income Tax
- - 691.00K (498.00K)
-
Income Tax - Current - Domestic
- - 200.00K (7.00K)
-
Income Tax - Current - Foreign
- - - -
-
Income Tax - Deferred - Domestic
- - 491.00K (491.00K)
-
Income Tax - Deferred - Foreign
- - - -
-
Income Tax Credits
- - - -
-
Equity in Earnings of Affiliates
- - - -
-
Other After Tax Income (Expense)
- - - (3.61M)
-
Consolidated Net Income
- (27.68M) 567.00K (71.80M)
Minority Interest Expense
- - - -
-
Net Income
- (27.68M) 567.00K (71.80M)
Net Income Growth
- - +102.05% -12,762.79%
-
Net Margin Growth
- - +375.50% -6,678.88%
-
Extraordinaries & Discontinued Operations
- - - -
-
Discontinued Operations
- - - -
-
Net Income After Extraordinaries
- (27.68M) 567.00K (71.80M)
Preferred Dividends
- - - -
-
Net Income Available to Common
- (27.68M) 567.00K (71.80M)
EPS (Basic)
- -0.6589 0.0135 -1.6162
EPS (Basic) Growth
- - +102.05% -12,071.85%
-
Basic Shares Outstanding
- 42.00M 42.00M 44.42M
EPS (Diluted)
- -0.6589 0.0135 -1.6162
EPS (Diluted) Growth
- - +102.05% -12,071.85%
-
Diluted Shares Outstanding
- 42.00M 42.00M 44.42M
EBITDA
- (27.39M) (44.70M) (79.42M)
EBITDA Growth
- - -63.21% -77.67%
-
EBITDA Margin
- - -29,603.97% -7,388.09%
-

Snapshot

Average Recommendation OVERWEIGHT Average Target Price 24.25
Number of Ratings 4 Current Quarters Estimate -0.128
FY Report Date 12 / 2025 Current Year's Estimate -0.133
Last Quarter’s Earnings -0.38 Median PE on CY Estimate N/A
Year Ago Earnings -7.26 Next Fiscal Year Estimate -2.213
Median PE on Next FY Estimate N/A

Earnings Per Share

This Quarter Next Quarter This Fiscal Next Fiscal
# of Estimates 4 3 4 4
Mean Estimate -0.13 -0.42 -0.13 -2.21
High Estimates 0.87 0.04 2.23 -1.79
Low Estimate -0.52 -0.83 -1.90 -3.05
Coefficient of Variance -522.67 -103.41 -1,565.94 -26.20

Analysts Recommendations

Current 1 Month Ago 3 Months Ago
BUY 3 4 4
OVERWEIGHT 0 0 0
HOLD 1 1 1
UNDERWEIGHT 0 0 0
SELL 0 0 0
MEAN Overweight Buy Buy

Insider Actions for Septerna Inc - SEPN

Date Name Shares Transaction Value
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 821,907 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $2.76 per share 2,268,463.32
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 826,907 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 Non-derivative transaction at $2.76 per share 2,282,263.32
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 402,212 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 0.00
Apr 7, 2025 Jeffrey T. Finer CEO and President; Director 397,212 Exercise or conversion of derivative security exempted pursuant to Rule 16b-3 0.00
Mar 11, 2025 R. Alan B. Ezekowitz Director 117,420 Open market or private purchase of non-derivative security Non-derivative transaction at $6.93 per share 813,720.60
Mar 7, 2025 R. Alan B. Ezekowitz Director 62,746 Open market or private purchase of non-derivative security Non-derivative transaction at $5.82 per share 365,181.72
Mar 7, 2025 R. Alan B. Ezekowitz Director 104,101 Open market or private purchase of non-derivative security Non-derivative transaction at $6 per share 624,606.00
Feb 28, 2025 Gilbert M. Labrucherie Chief Financial Officer 36,282 Open market or private purchase of non-derivative security Non-derivative transaction at $5.59 per share 202,816.38
Feb 28, 2025 Gilbert M. Labrucherie Chief Financial Officer 40,000 Open market or private purchase of non-derivative security Non-derivative transaction at $5.85 per share 234,000.00
Feb 27, 2025 Third Rock Ventures LLC 4,211,659 Open market or private purchase of non-derivative security Non-derivative transaction at $6 per share 25,269,954.00
Feb 24, 2025 Gilbert M. Labrucherie Chief Financial Officer 30,000 Open market or private purchase of non-derivative security Non-derivative transaction at $5.85 per share 175,500.00

Septerna Inc in the News