spyre therapeutics inc - SYRE

SYRE

Close Chg Chg %
16.36 0.09 0.52%

Open Market

16.45

+0.09 (0.52%)

Volume: 297.84K

Last Updated:

Sep 30, 2025, 3:29 PM EDT

Company Overview: spyre therapeutics inc - SYRE

SYRE Key Data

Open

$16.33

Day Range

15.82 - 16.46

52 Week Range

10.91 - 40.26

Market Cap

$988.16M

Shares Outstanding

60.40M

Public Float

51.03M

Beta

2.88

Rev. Per Employee

N/A

P/E Ratio

N/A

EPS

-$3.05

Yield

0.00%

Dividend

N/A

EX-DIVIDEND DATE

SHORT INTEREST

N/A

AVERAGE VOLUME

658.16K

 

SYRE Performance

1 Week
 
0.74%
 
1 Month
 
-0.79%
 
3 Months
 
3.81%
 
1 Year
 
-43.88%
 
5 Years
 
-90.68%
 

SYRE Analyst Ratings

  • Sell
  • Under
  • Hold
  • Over
  • Buy
Number of Ratings 13
Full Ratings ➔

About spyre therapeutics inc - SYRE

Spyre Therapeutics, Inc. is a clinical-stage biotechnology company, which engages in the development of next-generation human enzyme therapeutics as disruptive solutions for rare and other high-burden diseases. Its product, Pegzilarginase, is in a Phase 3 pivotal trial for the treatment of Arginase 1 Deficiency. The company was founded by George Georgiou and David G. Lowe on December 16, 2013 and is headquartered in Waltham, MA.

SYRE At a Glance

Spyre Therapeutics, Inc.
Building 23
Waltham, Massachusetts 02453
Phone 1-617-651-5940 Revenue 0.00
Industry Pharmaceuticals: Major Net Income -149,555,000.00
Sector Health Technology Employees 65
Fiscal Year-end 12 / 2025
View SEC Filings

SYRE Valuation

P/E Current N/A
P/E Ratio (with extraordinary items) N/A
P/E Ratio (without extraordinary items) N/A
Price to Sales Ratio N/A
Price to Book Ratio 3.875
Price to Cash Flow Ratio N/A
Enterprise Value to EBITDA -3.105
Enterprise Value to Sales N/A
Total Debt to Enterprise Value N/A

SYRE Efficiency

Revenue/Employee N/A
Income Per Employee -2,300,846.154
Receivables Turnover N/A
Total Asset Turnover N/A

SYRE Liquidity

Current Ratio 11.256
Quick Ratio 11.256
Cash Ratio 11.156

SYRE Profitability

Gross Margin N/A
Operating Margin N/A
Pretax Margin N/A
Net Margin N/A
Return on Assets -31.474
Return on Equity -42.619
Return on Total Capital -28.883
Return on Invested Capital -38.037

SYRE Capital Structure

Total Debt to Total Equity N/A
Total Debt to Total Capital N/A
Total Debt to Total Assets N/A
Long-Term Debt to Equity N/A
Long-Term Debt to Total Capital N/A
  • Income Statement
  • Balance Sheet
  • Cash Flow Statement

Annual Financials for Spyre Therapeutics Inc - SYRE

Collapse All in section
All values USD millions. 2021 2022 2023 2024 5-year trend
Sales/Revenue
- 18.74M 2.33M 886.00K
Sales Growth
- -87.57% -61.96% -100.00%
Cost of Goods Sold (COGS) incl D&A
- 2.00M 1.96M 964.00K
COGS excluding D&A
- - - -
-
Depreciation & Amortization Expense
- 2.00M 1.96M 964.00K
Depreciation
- 2.00M 1.96M 964.00K
Amortization of Intangibles
- - - -
-
COGS Growth
+23.21% -1.85% -50.92% -100.00%
Gross Income
- 16.74M 365.00K (78.00K)
Gross Income Growth
+1,130.67% -97.82% -121.37% +100.00%
Gross Profit Margin
- +89.32% +15.67% -8.80%
2021 2022 2023 2024 5-year trend
SG&A Expense
82.39M 85.15M 117.53M 208.57M
Research & Development
57.07M 58.58M 84.05M 162.79M
Other SG&A
25.32M 26.57M 33.49M 45.78M
SGA Growth
+3.17% +3.35% +38.04% +77.45%
Other Operating Expense
- - - -
-
Unusual Expense
- - - 224.67M
-
EBIT after Unusual Expense
(65.65M) (84.78M) (342.28M) (208.57M)
Non Operating Income/Expense
(11.00K) 830.00K 3.47M 599.00K
Non-Operating Interest Income
111.00K 837.00K 6.15M 21.31M
Equity in Earnings of Affiliates
- - - -
-
Interest Expense
- - - -
-
Interest Expense Growth
- - - -
-
Gross Interest Expense
- - - -
-
Interest Capitalized
- - - -
-
Pretax Income
(65.66M) (83.95M) (338.82M) (207.97M)
Pretax Income Growth
+18.83% -27.86% -303.59% +38.62%
Pretax Margin
- -350.39% -3,604.59% -38,241.08%
Income Tax
141.00K (136.00K) (26.00K) 51.00K
Income Tax - Current - Domestic
- - - -
-
Income Tax - Current - Foreign
- - - -
-
Income Tax - Deferred - Domestic
- - - -
-
Income Tax - Deferred - Foreign
- - - -
-
Income Tax Credits
- - - -
-
Equity in Earnings of Affiliates
- - - -
-
Other After Tax Income (Expense)
- - 243.91M 58.46M
-
Consolidated Net Income
(65.80M) (83.81M) (94.88M) (149.56M)
Minority Interest Expense
- - - -
-
Net Income
(65.80M) (83.81M) (94.88M) (149.56M)
Net Income Growth
+18.66% -27.38% -13.21% -57.62%
Net Margin Growth
- -351.14% -3,598.75% -10,709.14%
Extraordinaries & Discontinued Operations
- - - -
-
Discontinued Operations
- - - -
-
Net Income After Extraordinaries
(65.80M) (83.81M) (94.88M) (149.56M)
Preferred Dividends
- - - -
-
Net Income Available to Common
(65.80M) (83.81M) (94.88M) (149.56M)
EPS (Basic)
-25.0215 -24.8618 -13.757 -3.1801
EPS (Basic) Growth
+33.96% +0.64% +44.67% +76.88%
Basic Shares Outstanding
2.63M 3.37M 6.90M 47.03M
EPS (Diluted)
-25.0215 -24.8618 -13.757 -3.1801
EPS (Diluted) Growth
+33.96% +0.64% +44.67% +76.88%
Diluted Shares Outstanding
2.63M 3.37M 6.90M 47.03M
EBITDA
(63.65M) (82.82M) (116.65M) (208.57M)
EBITDA Growth
+20.30% -30.12% -40.85% -78.80%
EBITDA Margin
- -339.66% -3,555.90% -13,165.69%

Snapshot

Average Recommendation BUY Average Target Price 53.90
Number of Ratings 13 Current Quarters Estimate -0.836
FY Report Date 12 / 2025 Current Year's Estimate -2.815
Last Quarter’s Earnings -0.786 Median PE on CY Estimate N/A
Year Ago Earnings -3.18 Next Fiscal Year Estimate -3.243
Median PE on Next FY Estimate N/A

Earnings Per Share

This Quarter Next Quarter This Fiscal Next Fiscal
# of Estimates 12 8 12 12
Mean Estimate -0.84 -0.77 -2.81 -3.24
High Estimates -0.61 -0.49 -2.30 -2.49
Low Estimate -1.51 -1.00 -3.45 -4.20
Coefficient of Variance -28.67 -23.21 -13.31 -19.47

Analysts Recommendations

Current 1 Month Ago 3 Months Ago
BUY 11 11 11
OVERWEIGHT 1 1 1
HOLD 1 1 1
UNDERWEIGHT 0 0 0
SELL 0 0 0
MEAN Buy Buy Buy

Spyre Therapeutics Inc in the News